From CRISPR scissors to virus sensors
نویسندگان
چکیده
منابع مشابه
CRISPR/CAS9 Technology: A Revolutionary Molecular Scissors for Genome Editing and Genetic Research
Targeted gene modifications to animals’ especially mammalian genomes are central to understand the role of the gene in development, physiology, and different disease conditions. Functional elucidations of a gene or genetic variants require precise editing technologies. In conventional gene targeting methods, mutations of the gene or gene has been introduced into the genome by homologous recombi...
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Plant viruses infect many economically important crops, including wheat, cotton, maize, cassava, and other vegetables. These viruses pose a serious threat to agriculture worldwide, as decreases in cropland area per capita may cause production to fall short of that required to feed the increasing world population. Under these circumstances, conventional strategies can fail to control rapidly evo...
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One key dimension of the virtualization of the workplace is the formation of new types of partnerships where organizations let internal functions be handled by an external partner, the so-called outsourcing of services. The formation of an outsourcing partnership imposes the risk of knowledge-drainage on the client organization as specific internal competence decreases when the service provider...
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Hepatitis B virus persistence in infected hepatocytes is due to the presence of covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs. Antiviral therapies with nucleoside analogues inhibit replication of HBV DNA in capsids present in the cytoplasm of infected cells, but do not reduce or destroy nuclear cccDNA. To investigate whether cccDNA derived from infect...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-018-04975-8